Update on influenza vaccination of egg allergic patients

Khan DA ,. Lang DM ,. Oppenheimer JJ ,. Portnoy JM ,. Randolph CC ,. Schuller DE ,. Spector SL ,. Tilles SA ,. Wallace DV. Affiliations All authors 1. Electronic address: kelso. Share this article Share with email Share with twitter Share with linkedin Share with facebook. Abstract No abstract provided.

Full text links Read article at publisher's site DOI : References Articles referenced by this article 8 Adverse reactions to vaccines practice parameter update Kelso J Allergy Clin Immunol Safe administration of the seasonal trivalent influenza vaccine to children with severe egg allergy.

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Administration of influenza vaccines to egg allergic recipients: A practice parameter update Administration of influenza vaccines to patients with egg allergy: Update for the season. Influenza vaccination can be safely administered to most egg-allergic patients.

The use of inactivated influenza vaccine in children. Administering influenza vaccine to egg-allergic persons. Joining Europe PMC. Tools Tools overview. If you are someone who has more serious reactions to eating eggs or egg-containing foods, like angioedema, respiratory distress, lightheadedness, or recurrent emesis; or who required epinephrine or another emergency medical intervention, you can get any licensed flu vaccine i.

People with egg allergy can receive flu vaccines according to the recommendations above. A person who has previously experienced a severe allergic reaction to flu vaccine, regardless of the component suspected of being responsible for the reaction, should not get a flu vaccine again. Most flu vaccines today are produced using an egg-based manufacturing process and thus contain a small amount of egg protein called ovalbumin. Recombinant vaccine Flublok Quadrivalent and cell-based vaccine Flucelvax Quadrivalent are the only vaccines currently available that are completely egg free.

Can egg protein in flu vaccine cause allergic reactions in persons with a history of egg allergy? Yes, allergic reactions can happen, but they occur very rarely with the flu vaccines available in the United States today. Occasional cases of anaphylaxis, a severe life-threatening reaction that involves multiple organ systems and can progress rapidly, in egg-allergic persons have been reported to the Vaccine Adverse Event Reporting System VAERS after administration of flu vaccine.

Flu vaccines contain various components that may cause allergic reactions, including anaphylaxis. In a Vaccine Safety Datalink study, there were 10 cases of anaphylaxis after more than 7. Most of these cases of anaphylaxis were not related to the egg protein present in the vaccine.

CDC and the Advisory Committee on Immunization Practices continue to review available data regarding anaphylaxis cases following flu vaccines. How long after flu vaccination does a reaction occur in persons with a history of egg allergy? Allergic reactions can begin very soon after vaccination. However, the onset of symptoms is sometimes delayed. In a Vaccine Safety Datalink study of more than Of patients with a documented time to onset of symptoms, eight cases had onset within 30 minutes of vaccination, while in another 21 cases, symptoms were delayed more than 30 minutes following vaccination, including one case with symptom onset on the following day.

Therefore, all vaccine providers should be familiar with the office emergency plan, and be certified in cardiopulmonary resuscitation. To receive weekly email updates about Seasonal Flu, enter your email address:. Skip directly to site content Skip directly to page options Skip directly to A-Z link. Most recently, studies have demonstrated a low risk of giving the vaccine either in divided doses or as a single dose in a controlled setting without the need for skin testing.

Summary: In considering vaccination in a patient with a history of egg allergy, several factors should be weighed, including the severity of the egg allergy, the egg content of vaccines, and the setting of vaccine administration.

However, it appears that the risk of anaphylaxis to the influenza vaccine in patients with egg allergy may be much lower than previously thought, suggesting that in many cases skin testing may not be necessary.